Crocin, a plant-derived carotenoid, modulates microglial reactivity
نویسندگان
چکیده
منابع مشابه
Crocin, a plant-derived carotenoid, modulates microglial reactivity
Microglia activation plays an important role in immune responses in the CNS including the retina. Crocin, a plant-derived carotenoid, has been reported to possess anti-inflammatory, anti-apoptotic and anti-oxidative capacity in models of retinal damage and degeneration. If these neuroprotective effects could be mediated by direct modulation of microglial cells is unclear. Here, we examined the ...
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متن کاملThe Effect of the Crocus Sativus L. Carotenoid, Crocin, on the Polymerization of Microtubules, in Vitro
OBJECTIVE(S) Crocin, as the main carotenoid of saffron, has shown anti-tumor activity both in vitro and in vivo. Crocin might interact with cellular proteins and modulate their functions, but the exact target of this carotenoid and the other compounds of the saffron have not been discovered yet. Microtubular proteins, as one of the most important proteins inside the cells, have several function...
متن کاملNovel carotenoid cleavage dioxygenase catalyzes the first dedicated step in saffron crocin biosynthesis.
Crocus sativus stigmas are the source of the saffron spice and accumulate the apocarotenoids crocetin, crocins, picrocrocin, and safranal, responsible for its color, taste, and aroma. Through deep transcriptome sequencing, we identified a novel dioxygenase, carotenoid cleavage dioxygenase 2 (CCD2), expressed early during stigma development and closely related to, but distinct from, the CCD1 dio...
متن کاملRecent advances in understanding carotenoid-derived signaling molecules in regulating plant growth and development
Carotenoids (C40) are synthesized in plastids and perform numerous important functions in these organelles. In addition, carotenoids can be processed into smaller signaling molecules that regulate various phases of the plant's life cycle. Besides the relatively well-studied phytohormones abscisic acid (ABA) and strigolactones (SLs), additional carotenoid-derived signaling molecules have been di...
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ژورنال
عنوان ژورنال: Biochemistry and Biophysics Reports
سال: 2017
ISSN: 2405-5808
DOI: 10.1016/j.bbrep.2017.09.007